Drug interactions
Amisulpride + Benzhydrocodone / acetaminophen
Severity: Moderate
Amisulpride and Benzhydrocodone / acetaminophen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is a prodrug of the opioid hydrocodone, and amisulpride also causes sedation. Combining them can cause additive drowsiness, respiratory depression and hypotension.
What this interaction means in plain words
Amisulpride and Benzhydrocodone / acetaminophen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and dopamine antagonism.
What to do
Use the lowest effective doses for the shortest duration and monitor sedation and respiratory rate. Counsel the patient about avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Benzhydrocodone / acetaminophen?
MediHelp rates the interaction as moderate. Amisulpride and Benzhydrocodone / acetaminophen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is a prodrug of the opioid hydrocodone, and amisulpride also causes sedation. Combining them can cause additive drowsiness, respiratory depression and hypotension.
How serious is the interaction between Amisulpride and Benzhydrocodone / acetaminophen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor sedation and respiratory rate. Counsel the patient about avoiding driving and alcohol.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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