Drug interactions
Amisulpride + Brexanolone
Severity: Moderate
Amisulpride and Brexanolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone commonly causes excessive sedation and sudden loss of consciousness, and amisulpride adds further CNS depression. Concurrent use may deepen sedation during the infusion.
What this interaction means in plain words
Amisulpride and Brexanolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A positive modulation and antipsychotic sedative effects.
What to do
Monitor sedation and oxygen saturation continuously during brexanolone infusion. Interrupt or reduce the infusion if excessive sedation occurs, and consider holding sedating co-medications.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amisulpride and Brexanolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Brexanolone?
MediHelp rates the interaction as moderate. Amisulpride and Brexanolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone commonly causes excessive sedation and sudden loss of consciousness, and amisulpride adds further CNS depression. Concurrent use may deepen sedation during the infusion.
How serious is the interaction between Amisulpride and Brexanolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during brexanolone infusion. Interrupt or reduce the infusion if excessive sedation occurs, and consider holding sedating co-medications.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
