Drug interactions
Amisulpride + Buprenorphine subdermal implant
Severity: Moderate
Amisulpride and Buprenorphine subdermal implant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QT interval, and amisulpride has a similar effect. Both drugs also cause sedation, so the combination may add to arrhythmia risk and CNS depression.
What this interaction means in plain words
Amisulpride and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Obtain a baseline ECG and monitor QTc, electrolytes and sedation. Reduce the amisulpride dose or choose an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Buprenorphine subdermal implant?
MediHelp rates the interaction as moderate. Amisulpride and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QT interval, and amisulpride has a similar effect. Both drugs also cause sedation, so the combination may add to arrhythmia risk and CNS depression.
How serious is the interaction between Amisulpride and Buprenorphine subdermal implant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, electrolytes and sedation. Reduce the amisulpride dose or choose an alternative if QTc becomes prolonged.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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