Drug interactions
Amisulpride + Butalbital
Severity: Moderate
Amisulpride and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that causes CNS depression, and amisulpride adds sedation. Concurrent use may cause marked drowsiness and impaired coordination.
What this interaction means in plain words
Amisulpride and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from barbiturate GABA-A potentiation and antipsychotic sedative effects.
What to do
Monitor for excessive sedation and limit the butalbital dose and frequency. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Butalbital?
MediHelp rates the interaction as moderate. Amisulpride and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that causes CNS depression, and amisulpride adds sedation. Concurrent use may cause marked drowsiness and impaired coordination.
How serious is the interaction between Amisulpride and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and limit the butalbital dose and frequency. Advise patients to avoid driving and alcohol.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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