Drug interactions
Amisulpride + Difenoxin
Severity: Moderate
Amisulpride and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid-related antidiarrheal that can cause drowsiness and CNS depression. With amisulpride, sedation may be increased.
What this interaction means in plain words
Amisulpride and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid receptor agonism and dopamine D2 antagonism.
What to do
Use the lowest effective difenoxin dose for the shortest time and monitor for excessive sedation. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Difenoxin
Frequently asked questions
Can I take Amisulpride with Difenoxin?
MediHelp rates the interaction as moderate. Amisulpride and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid-related antidiarrheal that can cause drowsiness and CNS depression. With amisulpride, sedation may be increased.
How serious is the interaction between Amisulpride and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective difenoxin dose for the shortest time and monitor for excessive sedation. Advise against driving until the response is known.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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