Drug interactions
Amisulpride + Erythromycin base
Severity: Major
Amisulpride and Erythromycin base: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a macrolide associated with QT prolongation and torsades de pointes, particularly with intravenous use. Together with amisulpride, the proarrhythmic risk is increased.
What this interaction means in plain words
Amisulpride and Erythromycin base can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Use a non-QT-prolonging antibiotic where possible, such as one from a different class. If erythromycin is necessary, monitor the ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Erythromycin base?
MediHelp rates the interaction as major. Amisulpride and Erythromycin base can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin is a macrolide associated with QT prolongation and torsades de pointes, particularly with intravenous use. Together with amisulpride, the proarrhythmic risk is increased.
How serious is the interaction between Amisulpride and Erythromycin base?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antibiotic where possible, such as one from a different class. If erythromycin is necessary, monitor the ECG and electrolytes.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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