Drug interactions
Amisulpride + Erythromycin stearate
Severity: Major
Amisulpride and Erythromycin stearate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QT interval. Together they increase the chance of torsades de pointes, particularly in patients with electrolyte abnormalities or structural heart disease.
What this interaction means in plain words
Amisulpride and Erythromycin stearate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hERG potassium channel blockade leading to delayed ventricular repolarization.
What to do
Use a non-macrolide antibiotic where possible. If coadministered, check ECG at baseline and during therapy and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Erythromycin stearate?
MediHelp rates the interaction as major. Amisulpride and Erythromycin stearate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QT interval. Together they increase the chance of torsades de pointes, particularly in patients with electrolyte abnormalities or structural heart disease.
How serious is the interaction between Amisulpride and Erythromycin stearate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-macrolide antibiotic where possible. If coadministered, check ECG at baseline and during therapy and keep potassium and magnesium normal.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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