Drug interactions
Amisulpride + Esketamine
Severity: Moderate
Amisulpride and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, and concurrent use may deepen drowsiness and impair psychomotor performance. Esketamine is given in supervised sessions because of sedation and dissociation.
What this interaction means in plain words
Amisulpride and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression through different receptor mechanisms.
What to do
Observe patients for sedation throughout the post-dose monitoring period and avoid driving or hazardous tasks until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Esketamine?
MediHelp rates the interaction as moderate. Amisulpride and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, and concurrent use may deepen drowsiness and impair psychomotor performance. Esketamine is given in supervised sessions because of sedation and dissociation.
How serious is the interaction between Amisulpride and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe patients for sedation throughout the post-dose monitoring period and avoid driving or hazardous tasks until the next day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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