Drug interactions
Amisulpride + Fenoldopam
Severity: Moderate
Amisulpride and Fenoldopam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a peripheral dopamine D1 agonist and amisulpride blocks dopamine receptors, so the effects may oppose each other. Amisulpride's D2 blockade does not clearly counter fenoldopam's D1-mediated vasodilation, and fenoldopam does not cross the blood-brain barrier, so the clinical significance is uncertain.
What this interaction means in plain words
Amisulpride and Fenoldopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical pharmacodynamic antagonism at dopamine receptors; fenoldopam acts mainly on peripheral D1 receptors while amisulpride is a D2/D3 antagonist.
What to do
Monitor blood pressure response to fenoldopam when amisulpride is on board and titrate the infusion accordingly. Consider another antihypertensive if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Fenoldopam?
MediHelp rates the interaction as moderate. Amisulpride and Fenoldopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is a peripheral dopamine D1 agonist and amisulpride blocks dopamine receptors, so the effects may oppose each other. Amisulpride's D2 blockade does not clearly counter fenoldopam's D1-mediated vasodilation, and fenoldopam does not cross the blood-brain barrier, so the clinical significance is uncertain.
How serious is the interaction between Amisulpride and Fenoldopam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure response to fenoldopam when amisulpride is on board and titrate the infusion accordingly. Consider another antihypertensive if the response is inadequate.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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