Drug interactions
Amisulpride + Flurazepam
Severity: Moderate
Amisulpride and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting hypnotic benzodiazepine whose active metabolite accumulates, so combination with amisulpride may increase sedation, daytime impairment and falls. Older adults are particularly vulnerable.
What this interaction means in plain words
Amisulpride and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and dopamine D2 antagonism.
What to do
Use the lowest effective flurazepam dose and consider a shorter-acting alternative in older patients. Monitor for daytime sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Flurazepam?
MediHelp rates the interaction as moderate. Amisulpride and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting hypnotic benzodiazepine whose active metabolite accumulates, so combination with amisulpride may increase sedation, daytime impairment and falls. Older adults are particularly vulnerable.
How serious is the interaction between Amisulpride and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective flurazepam dose and consider a shorter-acting alternative in older patients. Monitor for daytime sedation and falls.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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