Drug interactions
Amisulpride + Gemtuzumab
Severity: Major
Amisulpride and Gemtuzumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, and amisulpride has a similar effect. Using both may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Amisulpride and Gemtuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of the QT interval; the mechanism for gemtuzumab is not well established.
What to do
Avoid if an alternative antipsychotic or antiemetic is possible. Otherwise monitor ECG and electrolytes during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Gemtuzumab?
MediHelp rates the interaction as major. Amisulpride and Gemtuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemtuzumab ozogamicin has been associated with QT prolongation, and amisulpride has a similar effect. Using both may increase the risk of ventricular arrhythmia.
How serious is the interaction between Amisulpride and Gemtuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antipsychotic or antiemetic is possible. Otherwise monitor ECG and electrolytes during treatment.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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