Drug interactions
Amisulpride + Ketamine
Severity: Moderate
Amisulpride and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and amisulpride may add to hypotension and QT prolongation risk. Ketamine's sympathomimetic effects may partially offset blood pressure changes but not the sedative effects.
What this interaction means in plain words
Amisulpride and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression; amisulpride dopamine antagonism with additional QT-prolonging potential.
What to do
Monitor sedation, blood pressure and ECG in patients with QT risk factors, and use lower ketamine doses where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Ketamine?
MediHelp rates the interaction as moderate. Amisulpride and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and amisulpride may add to hypotension and QT prolongation risk. Ketamine's sympathomimetic effects may partially offset blood pressure changes but not the sedative effects.
How serious is the interaction between Amisulpride and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and ECG in patients with QT risk factors, and use lower ketamine doses where appropriate.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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