Drug interactions
Amisulpride + Lamotrigine
Severity: Moderate
Amisulpride and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause somnolence and dizziness, so combined use may increase sedation and impair psychomotor performance. This is relevant for driving and for patients with psychiatric illness and epilepsy who take both.
What this interaction means in plain words
Amisulpride and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Monitor for excessive sedation and dizziness when starting or increasing either drug, and advise against driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Lamotrigine?
MediHelp rates the interaction as moderate. Amisulpride and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause somnolence and dizziness, so combined use may increase sedation and impair psychomotor performance. This is relevant for driving and for patients with psychiatric illness and epilepsy who take both.
How serious is the interaction between Amisulpride and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness when starting or increasing either drug, and advise against driving until tolerance is established.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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