Drug interactions
Amisulpride + Mobocertinib
Severity: Major
Amisulpride and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib carries a boxed warning for dose-related QTc prolongation and torsades de pointes, and amisulpride adds further QT risk. Concurrent use can result in serious arrhythmias.
What this interaction means in plain words
Amisulpride and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation via inhibition of cardiac repolarizing potassium currents.
What to do
Avoid the combination and choose a non-QT-prolonging alternative to amisulpride. If unavoidable, monitor ECG and electrolytes closely and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Mobocertinib?
MediHelp rates the interaction as major. Amisulpride and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib carries a boxed warning for dose-related QTc prolongation and torsades de pointes, and amisulpride adds further QT risk. Concurrent use can result in serious arrhythmias.
How serious is the interaction between Amisulpride and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging alternative to amisulpride. If unavoidable, monitor ECG and electrolytes closely and correct hypokalemia and hypomagnesemia.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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