Drug interactions
Amisulpride + Nitrous oxide
Severity: Moderate
Amisulpride and Nitrous oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrous oxide has sedative and anesthetic properties, and amisulpride may add to CNS depression and hypotension. The effect is usually short-lived and manageable in monitored settings.
What this interaction means in plain words
Amisulpride and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from NMDA antagonism and dopamine D2 antagonism.
What to do
Inform the anesthesia team of antipsychotic use and titrate sedation carefully. Monitor blood pressure and oxygenation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Nitrous oxide?
MediHelp rates the interaction as moderate. Amisulpride and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrous oxide has sedative and anesthetic properties, and amisulpride may add to CNS depression and hypotension. The effect is usually short-lived and manageable in monitored settings.
How serious is the interaction between Amisulpride and Nitrous oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of antipsychotic use and titrate sedation carefully. Monitor blood pressure and oxygenation.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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