Drug interactions
Amisulpride + Opium tincture
Severity: Moderate
Amisulpride and Opium tincture: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture contains morphine and other opium alkaloids that depress the central nervous system. Combined with amisulpride, sedation, dizziness and psychomotor impairment may be greater, and in higher doses respiratory depression and hypotension are possible.
What this interaction means in plain words
Amisulpride and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid receptor agonism and amisulpride's sedative and antipsychotic effects.
What to do
Use the lowest effective opioid dose and monitor sedation, respiratory rate and blood pressure, especially when starting or increasing doses. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Opium tincture?
MediHelp rates the interaction as moderate. Amisulpride and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium tincture contains morphine and other opium alkaloids that depress the central nervous system. Combined with amisulpride, sedation, dizziness and psychomotor impairment may be greater, and in higher doses respiratory depression and hypotension are possible.
How serious is the interaction between Amisulpride and Opium tincture?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor sedation, respiratory rate and blood pressure, especially when starting or increasing doses. Advise patients to avoid driving and alcohol.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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