Drug interactions
Amisulpride + Orphenadrine
Severity: Moderate
Amisulpride and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant with sedative and antihistaminic properties. Used with amisulpride, drowsiness and dizziness may be increased, and anticholinergic effects such as confusion, constipation and urinary retention may add up. Orphenadrine has also been linked to QT prolongation in overdose.
What this interaction means in plain words
Amisulpride and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and anticholinergic effects through different receptor mechanisms.
What to do
Monitor for oversedation, confusion and anticholinergic effects, particularly in older adults. Reduce the dose of one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Orphenadrine?
MediHelp rates the interaction as moderate. Amisulpride and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant with sedative and antihistaminic properties. Used with amisulpride, drowsiness and dizziness may be increased, and anticholinergic effects such as confusion, constipation and urinary retention may add up. Orphenadrine has also been linked to QT prolongation in overdose.
How serious is the interaction between Amisulpride and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and anticholinergic effects, particularly in older adults. Reduce the dose of one agent if symptoms occur.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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