Drug interactions
Amisulpride + Pentobarbital
Severity: Major
Amisulpride and Pentobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital is a barbiturate with strong CNS depressant effects. With amisulpride, sedation and psychomotor impairment can be markedly increased, and hypotension or respiratory depression is possible at higher barbiturate doses. Barbiturates can also lower the seizure threshold on withdrawal, and antipsychotics may lower it as well.
What this interaction means in plain words
Amisulpride and Pentobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression via GABA-A potentiation by pentobarbital and the sedative effects of amisulpride.
What to do
Use the lowest effective doses and monitor level of consciousness, respiratory status and blood pressure closely. Avoid use outpatient unless supervised.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amisulpride and Pentobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Pentobarbital?
MediHelp rates the interaction as major. Amisulpride and Pentobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentobarbital is a barbiturate with strong CNS depressant effects. With amisulpride, sedation and psychomotor impairment can be markedly increased, and hypotension or respiratory depression is possible at higher barbiturate doses. Barbiturates can also lower the seizure threshold on withdrawal, and antipsychotics may lower it as well.
How serious is the interaction between Amisulpride and Pentobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor level of consciousness, respiratory status and blood pressure closely. Avoid use outpatient unless supervised.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
