Drug interactions
Amisulpride + Phenobarbital
Severity: Moderate
Amisulpride and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a long-acting barbiturate that depresses the CNS, so combining it with amisulpride may increase drowsiness, impair coordination and reduce alertness. Antipsychotics may also lower seizure threshold, which can counteract the anticonvulsant purpose of phenobarbital.
What this interaction means in plain words
Amisulpride and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and the sedative properties of amisulpride.
What to do
Monitor sedation and seizure control, and start amisulpride at a low dose with gradual titration. Counsel patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Phenobarbital?
MediHelp rates the interaction as moderate. Amisulpride and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a long-acting barbiturate that depresses the CNS, so combining it with amisulpride may increase drowsiness, impair coordination and reduce alertness. Antipsychotics may also lower seizure threshold, which can counteract the anticonvulsant purpose of phenobarbital.
How serious is the interaction between Amisulpride and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure control, and start amisulpride at a low dose with gradual titration. Counsel patients to avoid alcohol and driving until the response is known.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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