Drug interactions
Amisulpride + Remifentanil
Severity: Moderate
Amisulpride and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride and remifentanil both depress the CNS, which can increase sedation and hypotension. Amisulpride also prolongs the QT interval, which matters in perioperative settings.
What this interaction means in plain words
Amisulpride and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; amisulpride has independent QT-prolonging action.
What to do
Titrate remifentanil to effect and monitor sedation, blood pressure and ECG. Correct potassium and magnesium before use in patients with QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Remifentanil?
MediHelp rates the interaction as moderate. Amisulpride and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amisulpride and remifentanil both depress the CNS, which can increase sedation and hypotension. Amisulpride also prolongs the QT interval, which matters in perioperative settings.
How serious is the interaction between Amisulpride and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remifentanil to effect and monitor sedation, blood pressure and ECG. Correct potassium and magnesium before use in patients with QT risk.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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