Drug interactions
Amisulpride + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Amisulpride and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta2-agonist that can cause small QTc increases and hypokalemia at higher exposure. With amisulpride the added risk is small at inhaled doses but may matter in patients with cardiac risk factors.
What this interaction means in plain words
Amisulpride and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia enhancing amisulpride's effect.
What to do
Use standard inhaled doses and check potassium in patients with cardiac risk factors. Obtain an ECG if other QT-prolonging drugs or heart disease are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Amisulpride and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta2-agonist that can cause small QTc increases and hypokalemia at higher exposure. With amisulpride the added risk is small at inhaled doses but may matter in patients with cardiac risk factors.
How serious is the interaction between Amisulpride and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard inhaled doses and check potassium in patients with cardiac risk factors. Obtain an ECG if other QT-prolonging drugs or heart disease are present.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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