Drug interactions
Amisulpride + Zolpidem
Severity: Moderate
Amisulpride and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can deepen drowsiness and impair psychomotor performance. Next-day impairment, falls and confusion are more likely, particularly in older patients.
What this interaction means in plain words
Amisulpride and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A agonism (zolpidem) and dopamine antagonism with sedative properties (amisulpride).
What to do
Start zolpidem at the lowest dose and counsel the patient about driving and operating machinery. Monitor for excessive sedation and reduce the dose if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Zolpidem?
MediHelp rates the interaction as moderate. Amisulpride and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can deepen drowsiness and impair psychomotor performance. Next-day impairment, falls and confusion are more likely, particularly in older patients.
How serious is the interaction between Amisulpride and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start zolpidem at the lowest dose and counsel the patient about driving and operating machinery. Monitor for excessive sedation and reduce the dose if it occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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