Drug interactions
Amitriptyline + Apomorphine
Severity: Moderate
Amitriptyline and Apomorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and orthostatic hypotension, and each has some potential to prolong the QT interval. Together they may increase sedation, falls, and arrhythmia risk, particularly in older patients or those with other QT risk factors.
What this interaction means in plain words
Amitriptyline and Apomorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Apomorphine belongs to Central Nervous System.
Why it happens
Additive CNS depression, hypotensive effects and QT-prolonging effects.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors, and monitor blood pressure on standing and sedation after starting or adjusting either drug. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Amitriptyline with Apomorphine?
MediHelp rates the interaction as moderate. Amitriptyline and Apomorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and orthostatic hypotension, and each has some potential to prolong the QT interval. Together they may increase sedation, falls, and arrhythmia risk, particularly in older patients or those with other QT risk factors.
How serious is the interaction between Amitriptyline and Apomorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors, and monitor blood pressure on standing and sedation after starting or adjusting either drug. Correct potassium and magnesium abnormalities.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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