Drug interactions
Amitriptyline + Aprepitant
Severity: Minor
Amitriptyline and Aprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline is metabolized partly by CYP3A4 along with CYP2C19 and CYP2D6. Aprepitant may modestly raise tricyclic levels, increasing anticholinergic effects, sedation and cardiac conduction effects.
What this interaction means in plain words
Amitriptyline and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, a secondary pathway of amitriptyline metabolism.
What to do
No routine dose change is needed. Monitor for sedation, anticholinergic effects and palpitations, especially in older adults or patients with heart disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Aprepitant?
MediHelp rates the interaction as minor. Amitriptyline and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amitriptyline is metabolized partly by CYP3A4 along with CYP2C19 and CYP2D6. Aprepitant may modestly raise tricyclic levels, increasing anticholinergic effects, sedation and cardiac conduction effects.
How serious is the interaction between Amitriptyline and Aprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for sedation, anticholinergic effects and palpitations, especially in older adults or patients with heart disease.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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