Drug interactions
Amitriptyline + Armodafinil
Severity: Minor
Amitriptyline and Armodafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak inhibitor of CYP2C19 and might raise amitriptyline levels slightly, though the effect is unlikely to be large. Its stimulant action opposes sedation, and both drugs can increase heart rate.
What this interaction means in plain words
Amitriptyline and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Armodafinil belongs to Central Nervous System.
Why it happens
Weak CYP2C19 inhibition by armodafinil, plus opposing and additive pharmacodynamic effects on alertness and heart rate.
What to do
Monitor for tricyclic adverse effects and heart rate or blood pressure changes. Adjust the amitriptyline dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Amitriptyline with Armodafinil?
MediHelp rates the interaction as minor. Amitriptyline and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak inhibitor of CYP2C19 and might raise amitriptyline levels slightly, though the effect is unlikely to be large. Its stimulant action opposes sedation, and both drugs can increase heart rate.
How serious is the interaction between Amitriptyline and Armodafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and heart rate or blood pressure changes. Adjust the amitriptyline dose if toxicity appears.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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