Drug interactions
Amitriptyline + Dantrolene
Severity: Moderate
Amitriptyline and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline is strongly sedating and dantrolene causes drowsiness and weakness, so together they can produce marked sedation and impaired alertness. Falls and cognitive impairment are a particular risk in older adults.
What this interaction means in plain words
Amitriptyline and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression from histamine H1 blockade and anticholinergic effects of the tricyclic with dantrolene's central effects.
What to do
Use the lowest effective doses and counsel on sedation and driving. Consider dose reduction, especially in elderly patients, if drowsiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Dantrolene?
MediHelp rates the interaction as moderate. Amitriptyline and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline is strongly sedating and dantrolene causes drowsiness and weakness, so together they can produce marked sedation and impaired alertness. Falls and cognitive impairment are a particular risk in older adults.
How serious is the interaction between Amitriptyline and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel on sedation and driving. Consider dose reduction, especially in elderly patients, if drowsiness develops.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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