Drug interactions
Amitriptyline + Dolasetron
Severity: Major
Amitriptyline and Dolasetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline prolongs QT and is serotonergic, and dolasetron also prolongs cardiac intervals. Combined use raises arrhythmia risk, with a small additional risk of serotonin syndrome.
What this interaction means in plain words
Amitriptyline and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT/conduction prolongation and possible additive serotonergic effects.
What to do
Prefer an antiemetic with less QT liability. If both are needed, obtain an ECG, correct electrolytes and monitor for arrhythmia and serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Dolasetron?
MediHelp rates the interaction as major. Amitriptyline and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amitriptyline prolongs QT and is serotonergic, and dolasetron also prolongs cardiac intervals. Combined use raises arrhythmia risk, with a small additional risk of serotonin syndrome.
How serious is the interaction between Amitriptyline and Dolasetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic with less QT liability. If both are needed, obtain an ECG, correct electrolytes and monitor for arrhythmia and serotonin toxicity.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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