Drug interactions
Amitriptyline + Eletriptan
Severity: Moderate
Amitriptyline and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with a tricyclic antidepressant carries a theoretical risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. Reported cases are rare and tricyclics are widely used with triptans for migraine prophylaxis.
What this interaction means in plain words
Amitriptyline and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity, through 5-HT1B/1D agonism by the triptan and serotonin reuptake inhibition by amitriptyline.
What to do
Counsel patients to report agitation, tremor, sweating or fever promptly. Monitor for serotonin toxicity when doses are started or increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Amitriptyline with Eletriptan?
MediHelp rates the interaction as moderate. Amitriptyline and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a triptan with a tricyclic antidepressant carries a theoretical risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. Reported cases are rare and tricyclics are widely used with triptans for migraine prophylaxis.
How serious is the interaction between Amitriptyline and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, sweating or fever promptly. Monitor for serotonin toxicity when doses are started or increased.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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