Drug interactions
Amitriptyline + Estradiol
Severity: Minor
Amitriptyline and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens have been reported to raise tricyclic antidepressant concentrations and adverse effects, while some reports suggest reduced antidepressant efficacy. Evidence is limited and inconsistent.
What this interaction means in plain words
Amitriptyline and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Estradiol belongs to Endocrine.
Why it happens
Mechanism not established; possible altered hepatic metabolism of the tricyclic by estrogens.
What to do
Monitor for increased anticholinergic or sedative effects and for changes in antidepressant response when estrogen is started or stopped, adjusting amitriptyline dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Amitriptyline with Estradiol?
MediHelp rates the interaction as minor. Amitriptyline and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens have been reported to raise tricyclic antidepressant concentrations and adverse effects, while some reports suggest reduced antidepressant efficacy. Evidence is limited and inconsistent.
How serious is the interaction between Amitriptyline and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased anticholinergic or sedative effects and for changes in antidepressant response when estrogen is started or stopped, adjusting amitriptyline dose accordingly.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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