Drug interactions
Amobarbital + Liothyronine
Severity: Moderate
Amobarbital and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can increase the hepatic breakdown of thyroid hormones, potentially lowering effective thyroid hormone levels. Patients on replacement therapy may develop signs of hypothyroidism.
What this interaction means in plain words
Amobarbital and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Liothyronine belongs to Endocrine.
Why it happens
Hepatic enzyme induction increases thyroid hormone metabolism and clearance.
What to do
Monitor thyroid function tests and clinical status after starting or stopping amobarbital, and adjust the liothyronine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
- Cholestyramine + Liothyronine Moderate
Frequently asked questions
Can I take Amobarbital with Liothyronine?
MediHelp rates the interaction as moderate. Amobarbital and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can increase the hepatic breakdown of thyroid hormones, potentially lowering effective thyroid hormone levels. Patients on replacement therapy may develop signs of hypothyroidism.
How serious is the interaction between Amobarbital and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor thyroid function tests and clinical status after starting or stopping amobarbital, and adjust the liothyronine dose accordingly.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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