Drug interactions
Carbonyl iron + Liothyronine
Severity: Moderate
Carbonyl iron and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron can bind liothyronine in the gut and reduce its absorption. This may lead to loss of thyroid hormone effect and higher TSH.
What this interaction means in plain words
Carbonyl iron and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbonyl iron belongs to Miscellaneous; Liothyronine belongs to Endocrine.
Why it happens
Iron forms insoluble complexes with thyroid hormone in the gastrointestinal tract, reducing absorption.
What to do
Separate administration by at least 4 hours. Monitor TSH and clinical status after iron is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Cholestyramine + Liothyronine Moderate
Frequently asked questions
Can I take Carbonyl iron with Liothyronine?
MediHelp rates the interaction as moderate. Carbonyl iron and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron can bind liothyronine in the gut and reduce its absorption. This may lead to loss of thyroid hormone effect and higher TSH.
How serious is the interaction between Carbonyl iron and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 4 hours. Monitor TSH and clinical status after iron is started or stopped.
What other medicines interact with Carbonyl iron?
MediHelp also lists interactions of Carbonyl iron with, for example, Aluminum hydroxide, Baloxavir marboxil, Calcium acetate. The full list is on the Carbonyl iron page.
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