Drug interactions
Carbamazepine + Liothyronine
Severity: Moderate
Carbamazepine and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower thyroid hormone levels, and patients on liothyronine may become under-replaced. Hypothyroid symptoms may appear.
What this interaction means in plain words
Carbamazepine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Liothyronine belongs to Endocrine.
Why it happens
Carbamazepine induces hepatic metabolism and glucuronidation of thyroid hormones.
What to do
Monitor TSH and free thyroid hormones after starting or stopping carbamazepine. Increase the liothyronine dose if clinically hypothyroid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
- Cholestyramine + Liothyronine Moderate
Frequently asked questions
Can I take Carbamazepine with Liothyronine?
MediHelp rates the interaction as moderate. Carbamazepine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can lower thyroid hormone levels, and patients on liothyronine may become under-replaced. Hypothyroid symptoms may appear.
How serious is the interaction between Carbamazepine and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH and free thyroid hormones after starting or stopping carbamazepine. Increase the liothyronine dose if clinically hypothyroid.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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