Drug interactions
Amitriptyline + Loratadine
Severity: Minor
Amitriptyline and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antihistaminic and amitriptyline is strongly sedating and anticholinergic. Loratadine adds little sedation, and any change in amitriptyline levels through transporters is theoretical.
What this interaction means in plain words
Amitriptyline and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
Theoretical P-glycoprotein effect and mild additive antihistaminic effects.
What to do
No routine adjustment; monitor for increased drowsiness or anticholinergic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Loratadine?
MediHelp rates the interaction as minor. Amitriptyline and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are antihistaminic and amitriptyline is strongly sedating and anticholinergic. Loratadine adds little sedation, and any change in amitriptyline levels through transporters is theoretical.
How serious is the interaction between Amitriptyline and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for increased drowsiness or anticholinergic effects.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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