Drug interactions
Amitriptyline + Melatonin
Severity: Minor
Amitriptyline and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative effects that may add to amitriptyline drowsiness. The clinical effect is generally small and manageable, and some data suggest amitriptyline may modestly raise melatonin levels.
What this interaction means in plain words
Amitriptyline and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive sedation; possible small pharmacokinetic effects on melatonin metabolism.
What to do
No routine change is required. Counsel patients about daytime drowsiness and reduce the melatonin dose if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Amitriptyline with Melatonin?
MediHelp rates the interaction as minor. Amitriptyline and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative effects that may add to amitriptyline drowsiness. The clinical effect is generally small and manageable, and some data suggest amitriptyline may modestly raise melatonin levels.
How serious is the interaction between Amitriptyline and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required. Counsel patients about daytime drowsiness and reduce the melatonin dose if sedation is excessive.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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