Drug interactions
Amitriptyline + Propylhexedrine
Severity: Minor
Amitriptyline and Propylhexedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled nasal decongestant with sympathomimetic activity. Tricyclics can alter sympathomimetic responses and, with excessive use, may produce hypertension and tachycardia. The effect is usually small at normal inhaled doses.
What this interaction means in plain words
Amitriptyline and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Tricyclic blockade of neuronal uptake of indirect sympathomimetics and of norepinephrine reuptake.
What to do
Advise using propylhexedrine only at labelled doses and for short periods. Monitor blood pressure in patients with cardiovascular disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Amitriptyline with Propylhexedrine?
MediHelp rates the interaction as minor. Amitriptyline and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propylhexedrine is an inhaled nasal decongestant with sympathomimetic activity. Tricyclics can alter sympathomimetic responses and, with excessive use, may produce hypertension and tachycardia. The effect is usually small at normal inhaled doses.
How serious is the interaction between Amitriptyline and Propylhexedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise using propylhexedrine only at labelled doses and for short periods. Monitor blood pressure in patients with cardiovascular disease.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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