Drug interactions
Amitriptyline + Risperidone
Severity: Moderate
Amitriptyline and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause sedation and orthostatic hypotension. Amitriptyline may also raise risperidone levels via CYP2D6 competition, adding to the risk of adverse effects.
What this interaction means in plain words
Amitriptyline and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depression, with possible CYP2D6-mediated pharmacokinetic interaction.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities, then monitor ECG, sedation and blood pressure. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Amitriptyline with Risperidone?
MediHelp rates the interaction as moderate. Amitriptyline and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and cause sedation and orthostatic hypotension. Amitriptyline may also raise risperidone levels via CYP2D6 competition, adding to the risk of adverse effects.
How serious is the interaction between Amitriptyline and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities, then monitor ECG, sedation and blood pressure. Use the lowest effective doses.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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