Drug interactions
Amitriptyline + Rizatriptan
Severity: Moderate
Amitriptyline and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic transmission, so there is a theoretical risk of serotonin syndrome. Serious reactions are uncommon in practice.
What this interaction means in plain words
Amitriptyline and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from serotonin reuptake inhibition and 5-HT1B/1D agonism.
What to do
Counsel on symptoms of serotonin syndrome and monitor after starting or increasing either drug. Discontinue one agent if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Amitriptyline with Rizatriptan?
MediHelp rates the interaction as moderate. Amitriptyline and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic transmission, so there is a theoretical risk of serotonin syndrome. Serious reactions are uncommon in practice.
How serious is the interaction between Amitriptyline and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on symptoms of serotonin syndrome and monitor after starting or increasing either drug. Discontinue one agent if toxicity is suspected.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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