Drug interactions
Amitriptyline + Stiripentol
Severity: Moderate
Amitriptyline and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and may add to the sedative effects of amitriptyline. Stiripentol also inhibits several CYP enzymes and could raise tricyclic levels.
What this interaction means in plain words
Amitriptyline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus possible CYP inhibition by stiripentol (CYP2C19, CYP3A4, CYP1A2) reducing amitriptyline metabolism.
What to do
Monitor for excess sedation and anticholinergic or cardiac effects, and reduce the amitriptyline dose if these occur. Counsel patients on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Amitriptyline with Stiripentol?
MediHelp rates the interaction as moderate. Amitriptyline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and may add to the sedative effects of amitriptyline. Stiripentol also inhibits several CYP enzymes and could raise tricyclic levels.
How serious is the interaction between Amitriptyline and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and anticholinergic or cardiac effects, and reduce the amitriptyline dose if these occur. Counsel patients on driving and alcohol.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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