Drug interactions
Amitriptyline + Tedizolid
Severity: Moderate
Amitriptyline and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor and amitriptyline blocks serotonin and norepinephrine reuptake. A serotonergic interaction is theoretically possible, although clinical trials of tedizolid showed little evidence of it.
What this interaction means in plain words
Amitriptyline and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Theoretical additive serotonergic effect from weak MAO inhibition plus monoamine reuptake inhibition.
What to do
Co-administration is acceptable when needed; monitor for features of serotonin syndrome, especially after starting or raising doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Tedizolid?
MediHelp rates the interaction as moderate. Amitriptyline and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor and amitriptyline blocks serotonin and norepinephrine reuptake. A serotonergic interaction is theoretically possible, although clinical trials of tedizolid showed little evidence of it.
How serious is the interaction between Amitriptyline and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-administration is acceptable when needed; monitor for features of serotonin syndrome, especially after starting or raising doses.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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