Drug interactions
Amitriptyline + Tiotropium-olodaterol
Severity: Moderate
Amitriptyline and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline can prolong the QT interval and, per olodaterol labelling, tricyclics may potentiate the cardiovascular effects of beta2-agonists, increasing ventricular arrhythmia risk. Amitriptyline's anticholinergic action may also add to tiotropium effects.
What this interaction means in plain words
Amitriptyline and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Tricyclic QT prolongation and adrenergic potentiation combined with beta2-agonist effects, plus additive antimuscarinic activity.
What to do
Use with caution in patients with cardiac disease and obtain an ECG if risk factors exist. Monitor for palpitations, urinary retention and dry mouth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Amitriptyline and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline can prolong the QT interval and, per olodaterol labelling, tricyclics may potentiate the cardiovascular effects of beta2-agonists, increasing ventricular arrhythmia risk. Amitriptyline's anticholinergic action may also add to tiotropium effects.
How serious is the interaction between Amitriptyline and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with caution in patients with cardiac disease and obtain an ECG if risk factors exist. Monitor for palpitations, urinary retention and dry mouth.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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