Drug interactions
Amitriptyline + Valbenazine
Severity: Moderate
Amitriptyline and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may prolong the QT interval at higher exposures, and amitriptyline also prolongs QT. Combined use may add to the risk of arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Amitriptyline and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors, and avoid combining with additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Amitriptyline with Valbenazine?
MediHelp rates the interaction as moderate. Amitriptyline and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine may prolong the QT interval at higher exposures, and amitriptyline also prolongs QT. Combined use may add to the risk of arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Amitriptyline and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors, and avoid combining with additional QT-prolonging drugs.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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