Drug interactions
Amlodipine + Amobarbital
Severity: Minor
Amlodipine and Amobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can lower amlodipine exposure by speeding up its hepatic breakdown. This may reduce the blood pressure or antianginal effect of amlodipine. The effect is usually modest but can matter during long-term barbiturate use.
What this interaction means in plain words
Amlodipine and Amobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Amobarbital belongs to Central Nervous System.
Why it happens
Barbiturates induce CYP3A4, increasing the metabolism of amlodipine.
What to do
Monitor blood pressure and anginal symptoms when a barbiturate is started or stopped. Increase the amlodipine dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine and Amobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amlodipine with Amobarbital?
MediHelp rates the interaction as minor. Amlodipine and Amobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital can lower amlodipine exposure by speeding up its hepatic breakdown. This may reduce the blood pressure or antianginal effect of amlodipine. The effect is usually modest but can matter during long-term barbiturate use.
How serious is the interaction between Amlodipine and Amobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms when a barbiturate is started or stopped. Increase the amlodipine dose if the response is inadequate.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
