Drug interactions
Amlodipine + Calcium carbonate
Severity: Minor
Amlodipine and Calcium carbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium can in theory antagonize the effect of calcium channel blockers, and hypercalcemia may reduce their antihypertensive effect. At usual supplemental doses with normal calcium levels, clinically significant loss of effect is uncommon.
What this interaction means in plain words
Amlodipine and Calcium carbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Elevated extracellular calcium may pharmacodynamically oppose L-type calcium channel blockade.
What to do
No routine change is needed; monitor blood pressure if high-dose calcium or vitamin D is started and check serum calcium if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Calcium carbonate?
MediHelp rates the interaction as minor. Amlodipine and Calcium carbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium can in theory antagonize the effect of calcium channel blockers, and hypercalcemia may reduce their antihypertensive effect. At usual supplemental doses with normal calcium levels, clinically significant loss of effect is uncommon.
How serious is the interaction between Amlodipine and Calcium carbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood pressure if high-dose calcium or vitamin D is started and check serum calcium if response is lost.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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