Drug interactions
Amlodipine + Calcium gluconate
Severity: Moderate
Amlodipine and Calcium gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium gluconate can raise ionized calcium and blunt the vasodilating and hypotensive effects of amlodipine. It is used therapeutically to counter calcium channel blocker overdose. Oral calcium gluconate at usual doses has little effect.
What this interaction means in plain words
Amlodipine and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.
Why it happens
Increased extracellular calcium pharmacodynamically opposes calcium channel blockade.
What to do
Monitor blood pressure and serum calcium when intravenous calcium gluconate is given to a patient on amlodipine. Anticipate a reduced antihypertensive effect during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Amlodipine with Calcium gluconate?
MediHelp rates the interaction as moderate. Amlodipine and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can raise ionized calcium and blunt the vasodilating and hypotensive effects of amlodipine. It is used therapeutically to counter calcium channel blocker overdose. Oral calcium gluconate at usual doses has little effect.
How serious is the interaction between Amlodipine and Calcium gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium when intravenous calcium gluconate is given to a patient on amlodipine. Anticipate a reduced antihypertensive effect during treatment.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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