Drug interactions
Amlodipine + Carbamazepine
Severity: Moderate
Amlodipine and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a potent CYP3A4 inducer and can lower amlodipine exposure. The antihypertensive or antianginal effect of amlodipine may be reduced, and the effect can fade over several weeks as induction develops.
What this interaction means in plain words
Amlodipine and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4, increasing amlodipine metabolism.
What to do
Monitor blood pressure and symptoms after starting or stopping carbamazepine, and increase the amlodipine dose if needed. Reduce the dose again if carbamazepine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amlodipine with Carbamazepine?
MediHelp rates the interaction as moderate. Amlodipine and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is a potent CYP3A4 inducer and can lower amlodipine exposure. The antihypertensive or antianginal effect of amlodipine may be reduced, and the effect can fade over several weeks as induction develops.
How serious is the interaction between Amlodipine and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms after starting or stopping carbamazepine, and increase the amlodipine dose if needed. Reduce the dose again if carbamazepine is withdrawn.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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