Drug interactions
Amlodipine + Clevidipine
Severity: Moderate
Amlodipine and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dihydropyridine calcium channel blockers, so using them together gives additive vasodilation and blood pressure reduction. Clevidipine is a short-acting intravenous agent titrated to effect, so oral amlodipine changes the dose needed. Excess hypotension or reflex tachycardia can result.
What this interaction means in plain words
Amlodipine and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Clevidipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic L-type calcium channel blockade in vascular smooth muscle.
What to do
Titrate clevidipine against blood pressure with continuous monitoring, expecting lower infusion needs in patients taking amlodipine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Clevidipine
Frequently asked questions
Can I take Amlodipine with Clevidipine?
MediHelp rates the interaction as moderate. Amlodipine and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dihydropyridine calcium channel blockers, so using them together gives additive vasodilation and blood pressure reduction. Clevidipine is a short-acting intravenous agent titrated to effect, so oral amlodipine changes the dose needed. Excess hypotension or reflex tachycardia can result.
How serious is the interaction between Amlodipine and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine against blood pressure with continuous monitoring, expecting lower infusion needs in patients taking amlodipine.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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