Drug interactions
Amlodipine + Dasatinib
Severity: Minor
Amlodipine and Dasatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and could modestly raise amlodipine levels. This may cause more edema or hypotension. Dasatinib itself can cause fluid retention and peripheral edema, which may be confused with amlodipine effects.
What this interaction means in plain words
Amlodipine and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Dasatinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by dasatinib reduces amlodipine clearance.
What to do
Monitor blood pressure and peripheral edema. Reduce the amlodipine dose if hypotension or marked edema occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Amlodipine with Dasatinib?
MediHelp rates the interaction as minor. Amlodipine and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor and could modestly raise amlodipine levels. This may cause more edema or hypotension. Dasatinib itself can cause fluid retention and peripheral edema, which may be confused with amlodipine effects.
How serious is the interaction between Amlodipine and Dasatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and peripheral edema. Reduce the amlodipine dose if hypotension or marked edema occurs.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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