Drug interactions
Amlodipine + Dronedarone
Severity: Moderate
Amlodipine and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and can raise amlodipine levels. Dronedarone also slows sinus and AV nodal conduction, and combined hypotension or bradycardia may occur, though amlodipine has little direct nodal effect.
What this interaction means in plain words
Amlodipine and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by dronedarone increases amlodipine exposure, with additive hemodynamic effects.
What to do
Monitor blood pressure, heart rate and edema when combining. Use a low initial amlodipine dose and check the ECG if rate-slowing agents are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Amlodipine with Dronedarone?
MediHelp rates the interaction as moderate. Amlodipine and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and can raise amlodipine levels. Dronedarone also slows sinus and AV nodal conduction, and combined hypotension or bradycardia may occur, though amlodipine has little direct nodal effect.
How serious is the interaction between Amlodipine and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema when combining. Use a low initial amlodipine dose and check the ECG if rate-slowing agents are also used.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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