Drug interactions
Amlodipine + Eslicarbazepine
Severity: Minor
Amlodipine and Eslicarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak CYP3A4 inducer and may modestly lower amlodipine concentrations. The clinical effect is likely small but could reduce blood pressure control.
What this interaction means in plain words
Amlodipine and Eslicarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by eslicarbazepine increases amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping eslicarbazepine. Increase the amlodipine dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Amlodipine with Eslicarbazepine?
MediHelp rates the interaction as minor. Amlodipine and Eslicarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eslicarbazepine is a weak CYP3A4 inducer and may modestly lower amlodipine concentrations. The clinical effect is likely small but could reduce blood pressure control.
How serious is the interaction between Amlodipine and Eslicarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping eslicarbazepine. Increase the amlodipine dose if control is inadequate.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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