Drug interactions
Amlodipine + Flibanserin
Severity: Moderate
Amlodipine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may modestly raise flibanserin exposure. The effect is generally small with a single weak inhibitor, but flibanserin can cause hypotension, syncope and sedation, and amlodipine adds its own blood pressure lowering effect.
What this interaction means in plain words
Amlodipine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Flibanserin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4-mediated flibanserin metabolism, plus additive hypotensive effects.
What to do
Monitor blood pressure and for dizziness or syncope, especially when other CYP3A4 inhibitors are also taken. Advise the patient to avoid alcohol and to take flibanserin at bedtime.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Flibanserin?
MediHelp rates the interaction as moderate. Amlodipine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may modestly raise flibanserin exposure. The effect is generally small with a single weak inhibitor, but flibanserin can cause hypotension, syncope and sedation, and amlodipine adds its own blood pressure lowering effect.
How serious is the interaction between Amlodipine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for dizziness or syncope, especially when other CYP3A4 inhibitors are also taken. Advise the patient to avoid alcohol and to take flibanserin at bedtime.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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